The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells
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چکیده
منابع مشابه
Canine Appendicular Osteosarcoma: Diagnosis and Palliative Treatment
Email comments/questions to [email protected], fax 800-556-3288, or log on to www.VetLearn.com Osteosarcoma (OSA) is the most common primary bone tumor of the appendicular skeleton in dogs. Chondrosarcoma (CSA), fibrosarcoma (FSA), and hemangiosarcoma (HSA) are also considered primary bone tumors, although they are diagnosed much less frequently. Other tumors with skeletal involvement, s...
متن کاملThe effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro
BACKGROUND Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6-12 months despite these treatments. Taurolidine, a derivative of taurine, has anti-tumor and anti-angiogenic effects agains...
متن کاملCanine Appendicular Osteosarcoma: Curative-Intent Treatment
Dogs with appendicular osteosarcoma, the most common canine primary bone tumor, can be managed with either palliative or curative-intent therapy. Curative-intent techniques must address both the local bone tumor and the potential for development of metastatic disease. Limb amputation is the most common procedure for managing the local tumor. Limb-sparing techniques, both surgical and nonsurgica...
متن کاملPrognostic factors in canine appendicular osteosarcoma – a meta-analysis
BACKGROUND Appendicular osteosarcoma is the most common malignant primary canine bone tumor. When treated by amputation or tumor removal alone, median survival times (MST) do not exceed 5 months, with the majority of dogs suffering from metastatic disease. This period can be extended with adequate local intervention and adjuvant chemotherapy, which has become common practice. Several prognostic...
متن کاملEvaluation of P16 expression in canine appendicular osteosarcoma
BACKGROUND Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even with aggressive surgical treatment combined with chemotherapy, the majority of dogs diagnosed with OSA live less than 1 year from the time of diagnosis. The ability to identify ca...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0206427